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The final proposed mechanism of RBC vasodilation in the existence of nitrite will be the reduction of nitrite to NO by Hb. Brooks first researched the nitrite Hb conversation in 1937 which do the job was later on extended by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to type metHb and NO (Brooks, 1937; Doy